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Generic Name: furosemide, dosage Form: tablet, medically reviewed on March 1, 2018, show On This lasix dose Page. View All, lasix (furosemide) Tablets 20, 40, and 80mg, rx Only. Warning, lasix (furosemide) is lasix dose a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. Therefore, careful medical supervision is required and dose and dose schedule must be adjusted to the individual patients needs (see. Dosage AND administration ). Lasix Description, lasix is a diuretic which is an anthranilic acid derivative. Lasix tablets for oral administration contain furosemide as the active ingredient and the following inactive ingredients: lactose monohydrate NF, magnesium stearate NF, starch NF, talc USP, and colloidal silicon dioxide. Chemically, it is acid. Lasix is available as white tablets for oral administration in dosage strengths of lasix dose 20, 40 and 80mg. Furosemide is a white to off-white odors crystalline powder. It is practically insoluble in water, sparingly soluble in alcohol, freely soluble in dilute alkali solutions and insoluble in dilute acids. The CAS Registry Number is 54-31-9. The structural formula is as follows: Lasix - Clinical Pharmacology, investigations into the mode of action of Lasix have utilized micropuncture studies in rats, stop flow experiments in dogs lasix dose and various clearance studies in both humans and experimental animals. It has been demonstrated that Lasix inhibits primarily the absorption of sodium and chloride not only in the proximal and distal tubu but also in the loop of Henle. The high degree of efficacy is largely due to the unique site of action. The action on the distal tubule is independent of any inhibitory effect on carbonic anhydrase and aldosterone. Recent evidence suggests that furosemide glucuronide is the only or at least the major biotransformation product of furosemide in man. Furosemide is extensively bound to plasma proteins, mainly to albumin. Plasma concentrations ranging from 1 to 400 g/mL are 91 to 99 bound in healthy individuals. The unbound fraction averages.3.1 at therapeutic concentrations. The onset of diuresis following oral administration is within 1 hour. The peak effect occurs within the first or second hour. The duration of diuretic effect is 6 to 8 hours. In fasted normal men, the mean bioavailability of furosemide from Lasix Tablets and Lasix Oral Solution is 64 and 60, respectively, of that from an intravenous injection of the drug. Although furosemide is more rapidly absorbed from the oral solution (50 minutes) than from the tablet (87 minutes peak plasma levels and area under the plasma concentration-time curves do not differ significantly. Peak plasma concentrations increase with increasing dose but times-to-peak do not differ among doses. The terminal half-life of furosemide is approximately 2 hours. Significantly more furosemide is excreted in urine following the IV injection than after the tablet or oral solution. There are no significant differences between the two oral formulations in the amount of unchanged drug excreted in urine.

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